Second person in history reportedly cured of HIV

07 March, 2019, 13:00 | Author: Jerome Frank
  • Timothy Brown previously known

Globally, 36.9 million people were living with HIV at the end of 2017, with 59 percent receiving antiretroviral treatment, according the World Health Organization.

The therapy had an early success with Timothy Ray Brown, a US man treated in Germany who is 12 years post-transplant and still free of HIV.

The HIV positive London Patient was given a transplant of stem cells from a donor who had the rare gene mutation CCR5 which is related to HIV resistance.

The London patient, who was being treated for cancer, has now been in remission from HIV for 18 months and is no longer taking HIV drugs.

"The hope is that this will eventually lead to a safe, cost-effective and easy strategy to achieve these results using gene technology or antibody techniques", Pozniak said. Nearly one million people die annually from HIV-related causes.

The man, who has been identified only as the "London patient", was diagnosed with HIV in 2003 and advanced Hodgkin's lymphoma in 2012.

"Two factors are likely at play - the new bone marrow is resistant to HIV and also the new bone marrow is actively eliminating any HIV-infected cells through something called graft versus host disease".

Regular testing has confirmed that the patient's viral load remained undetectable since then. That's key because HIV uses that receptor to gain entry into the cells. Public health experts have a bullish plan to end HIV in the U.S. by 2030, but it does not involve expensive and risky bone-marrow transplants.

Brown, now 52, reportedly lives in Palm Springs, California and is still clear of HIV to this day.

London man becomes second in world to be cured of HIV
London HIV patient becomes world's second AIDS cure hope

This is the second time scientists have done this - the first person cured of AIDS was an American man named Timothy Brown (originally nicknamed "the Berlin patient").

Experts who study AIDS say the success of the Berlin patient and the London patient is very important.

"They used a reduced intense conditioning regimen but I think that had no influence on the outcome", he said. Both required a bone marrow transplant, which allowed physicians to introduce HIV-resistant stem cells into their bodies.

The study also claims that replacing the infected patients' cells with the mutated ones seemed to keep HIV from coming back after the treatment.

The "London patient" case, cautiously reported in the journal Nature as still too "premature" to be declared a cure, comes a decade after Timothy Brown, known in medical circles as the "Berlin patient" was cured by a similar stem cell transplant, galvanizing the field of HIV research and sparking the search for a cure.

Doctors in London say they have apparently eradicated HIV from a patient's body.

The cure for HIV has been invented and medically certified, the President of the United States of America Donald Trump has revealed. Now, tests show he has no sign of the HIV virus in his blood.

"There are actually many strategies right now that are currently being pursued", Henrich said. "Nobody doubted the truth of the report with the Berlin patient, but it was one patient - and which of the many things that were done to him contributed to the apparent cure?" The additional risks of aggressive chemotherapy and possible periods of immune dysfunction also point towards the lower-risk anti-retroviral drugs being a better and cheaper option. "I do have hope".

"I did not want to be the only person in the world cured of HIV", Brown wrote in a medical journal in 2015, explaining why he made a decision to reveal his identity.

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